19 of Medvedev's twenty-one titles have been earned on hard courts
A revitalized the Russian player secured his maiden championship for 882 days with success over Corentin Moutet in the competition title decider.
The athlete, a ex- number one, has experienced a torrid season, winning just one win at the Grand Slams and suffering a difficult moment at the New York tournament.
The player's unpredictability on the tennis tour - and struggles with his service game in especial - resulted in him dropping out of the world's top 10 and eventually splitting with long-time mentor his previous coach.
Now training with Thomas Johansson and Rohan Goetzke, he has steadily advanced in the last few weeks - climaxing in a closely contested 7-5 4-6 6-3 triumph over Frenchman Moutet.
It is his initial championship after the Italian tournament and initial on a hard surface from that period of the previous year.
The win also signifies Medvedev has achieved twenty-one victories at twenty-one various events.
"For the first time I am participating in a tournament with my both daughters simultaneously, so to get a trophy is especially meaningful," said ranked player Medvedev.
"This victory is in tribute of my younger daughter my daughter, because the maiden victory I got when my child her name was born was for her."
Medvedev, the past champion, had lost his last six title deciders, featuring in Halle previously this season.
Medvedev's defensive strategy and regular reactions on the playing surface had led some to doubt if his ability to perform at the top level was over.
However the 29-year-old has altered his approach in recent weeks, striving to advance forward and play positively, backed up by an enhanced serve.
The champion recovered from a disadvantage in the initial set against the challenging Moutet, winning 4 of the last five exchanges to go ahead.
Both players swapped service breaks in the second set before Moutet, striving for his initial tour victory, seized the initiative to create a decider.
Moutet defended four initial chances in a competitive deciding set before Medvedev broke to 15 to close out the victory.
Suitably, Medvedev secured victory with a rally at the front of the court, with Moutet unable to handle a return after two hours and 38 minutes.